Description
a well experienced medical professional writer is invited to complete this work WHICH IS NOT A SIMPLE WRITING TASK …please this is not a simple writing task …it is a full clinical dermatology research paper that should start with abstract , introduction , aim , methodology , results , analysis , discussions and literature review , tables and graphs with their legend are essential ,conclusions and recommendations . please you need to be professional in SPSS software . Data and proposal will be provided to you with excel sheet which contains information about the TWO treated groups of patients . the citation of the references should be of Vancouver type , dont use footnotes Comparative clinical study of efficacy of Dermapen ( microneedling) versus intralesional triamcinolon injection in the treatment of alopecia areata Background: Alopecia areata is a chronic inflammatory T cell mediated autoimmune skin disease characterized by patches of non-scaring alopecia mainly seen on the scalp and face. The life time risk is about 1.6 % and there is no age, sex, ethnicity predilection. Family history might be seen in up to 25 percent of patients and up to 80 percent of patients may have spontaneous hair regrowth in less than a year without any treatment. Many options of alopecia areata treatment have been described but unfortunately none has been shown to affect the long term prognosis. Intralesional triamcinolone injection has been widely used as a mainstay of treatment; however, new options like microneedling and fractional laser treatment have been described to be effective too. Objective: To compare the efficacy and safety of intralesional triamcinolone injection versus microneedling ( Dermapen ) in the treatment of alopecia areata patients. 100 patients attending the dermatology clinic were randomized into two groups using simple random numbers table Full history, exam taken, demographic data recorded, site, number and size of alopecia areata patches recorded
Comparative clinical study of efficacy of Dermapen ( microneedling) versus intralesional triamcinolon injection in the treatment of alopecia areata
Background:
Alopecia areata is a chronic inflammatory T cell mediated autoimmune skin disease characterized by patches of non-scaring alopecia mainly seen on the scalp and face. The life time risk is about 1.6 % and there is no age, sex, ethnicity predilection. Family history might be seen in up to 25 percent of patients and up to 80 percent of patients may have spontaneous hair regrowth in less than a year without any treatment. Many options of alopecia areata treatment have been described but unfortunately none has been shown to affect the long term prognosis. Intralesional triamcinolone injection has been widely used as a mainstay of treatment; however, new options like microneedling and fractional laser treatment have been described to be effective too.
Objective:
To compare the efficacy and safety of intralesional triamcinolone injection versus microneedling ( Dermapen ) in the treatment of alopecia areata patients.
100 patients attending the dermatology clinic were randomized into two groups using simple random numbers table
Full history, exam taken, demographic data recorded, site, number and size of alopecia areata patches recorded
Inclusion criteria:
Patients above the age of 18 years , one patch or more of alopecia areata , and less than 6 patches ,for 6 months or more but less than 2 years ,involves less than 50 percent of the scalp , should not have received steroid( topical on the lesions , intralesional injection , or systemic over the last 12 weeks )
Exclusion criteria:
Active scalp disease of any origin , chronic illnesses like diabetes , hypertension , liver and kidney disease , pregnant patients , lactating patients , patient with low immunity, steroid allergy , bleeding tendency , .
Diagnosis : clinical by naked eye and by using dermatoscope.
Patients were randomly distributed into two groups:
A: 50 patients, 36 males , 14 females, age between 18-53
Treated with intralesional triamcinolone injections , 2.5mg/ml, maximum 3ml per session (mixed with 1 % lidocaine in a sterile insulin syringe as 1:7) injected intradermally, at 45 degrees,using 0.5-inch long 30-gauge needle, started from the periphery of the patch and moved on to the center 0.1 ml/point injections at 0.5- 1cm intervals, every 1 month for maximum 3 session , side effects were recorded .
B:50 patients , 37 males , 13 females , age 18-50
Treated with Dermapen , 12 needles ,using lidocaine 10 percent cream under occlusion for 20 minutes , then a session is done by passing the needles on the alopecia areata patch till pinpoint bleeding spots seen . the patients had one session every 2 weeks for a total of 6 sessions . each session was followed by muporicine cream twice daily for 10 days
The results of both regimens were assessed using Mean Improvement Score (MISP), and patient satisfaction.
MISP: was assessed using naked eye and dermatoscope
[<25% = no or minimal improvement,
25–49% = moderate,
50–74% = marked,
>75%– 99= excellent
100%= complete improvement]
patient satisfaction using a 10
point VAS (0–10; 0 level “Not satisfied at all,” 10 level “completely satisfied
